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They include AKT protein kinase B (PKB), AP-1 activator protein-1, BDNF brain-derived neurotrophic factor, COX cyclooxygenase, ERK extracellular signal-regulated kinase, GDNF glial-derived neurotrophic factor, GFAP glial fibrillary acidic protein, GSK-3 glycogen synthase kinase-3, HO-1 hemoxygenase-1, IFN- interferon-, iNOS inducible NO synthase, JAK/STAT janus kinase/signal transducer and activator of transcription, JNK c-Jun N-terminal kinase, MAPK mitogen-activated protein kinase, MCP-1 monocyte chemoattractant protein-1, NF-B nuclear factor kappa-light-chain-enhancer of activated B cells
FIGURE 1 Deregulation of HGF/C-Met Mediates Cancer The strict regulation of HGF/c-Met signal transduction, observed in growth and regeneration, results in different degrees of maladjustment in various cancers, especially in the case of drug resistance or metastasis (Sierra and Tsao, 2011
Molecular Therapy / PMC (2017) 7
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